HBOC PANEL

• Targeted NGS solution which covers SNVs, indels, CNVs,Alu insertions and Boland inversions) associated with Hereditary Breast and Ovarian Cancer (HBOC), Lynch and various intestinal polyposis syndromes.

• It is 105kb panel which target 26 genes ie ABRAXAS1, APC, ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, EPCAM, MLH1, MRE11, MSH2, MSH6, MUTYH, NBN, PALB2, PIK3CA, PMS2, PMS2CL1, PTEN, RAD50, RAD51C, RAD51D, STK11, TP53, XRCC2.

• It guarantees high on-target rate and coverage uniformity even in GC-rich regions, including the first exon.

• Analytical Performance- Specificity, Sensitivity, Accuracy is 100% & Precision is 99.86%.

• The diagnosis of the presence of germline mutation in cancer predisposing gene in affected individual will help: